Neurological symptoms in psoriasis patients under treatment with infliximab
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چکیده
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modern surgical techniques in treatment of patients with cleft lip & cleft palate
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15 صفحه اولTreatment of severe psoriasis with infliximab
Psoriasis is a chronic, immune mediated inflammatory disease characterized by increased cell signalling via cytokines and chemokines on a background of up-regulated gene expression. There is substantial evidence that psoriasis should be regarded as more than a cutaneous disease; major psychological morbidity and increased mortality from cardiovascular disease and cancer are increasingly recogni...
متن کاملInfliximab in the treatment of plaque psoriasis
10.1586/14750708.4.4.399 © 2 Plaque psoriasis is a chronic and immune-mediated skin disease that affects approximately 1–3% of the Caucasian population. TNF-α is a proinflammatory cytokine that plays a critical role in the pathogenesis of psoriasis. Infliximab is a chimeric anti-TNF-α monoclonal antibody with high affinity for soluble and cell-surface transmembrane TNF-α. Results from Phase II ...
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متن کامل
Infliximab for the treatment of plaque psoriasis
Infliximab is a monoclonal antibody that targets tumor necrosis factor-alpha (TNFalpha). It is used in the treatment of a number of inflammatory disorders including severe plaque psoriasis. TNFalpha is thought to have a major role in psoriasis by promoting an inflammatory infiltrate into the skin and inducing keratinocyte proliferation and preventing keratinocyte apoptosis, which directly contr...
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ژورنال
عنوان ژورنال: Asian Pacific Journal of Tropical Biomedicine
سال: 2015
ISSN: 2221-1691
DOI: 10.1016/j.apjtb.2015.05.020